Media Additives
Medchemexpress LLC Dehydrodiisoeugenol | 2680-81-1 | 326.39 | 5 MG
Dehydrodiisoeugenol is an orally active compound demonstrating anti-inflammatory and anti-tumor properties. It is utilized in research focusing on colorectal cancer, inflammatory conditions, and ulcerative colitis.
- Inhibits proliferation of colorectal cancer cells.
- Induces apoptosis, autophagy, and cell cycle arrest.
- Exerts anti-inflammatory effects by inhibiting NF-κB activation and COX-2 expression.
- Reduces self-renewal and colony-forming capacities of colorectal cancer cells.
- Ameliorates ulcerative colitis.
- Significantly inhibits tumor growth in mouse models with low toxicity.
Medchemexpress LLC FGFR2-IN-2 | 2677709-81-6 | 98.3% | 370.45 | C23H22N4O | 5 MG
FGFR2-IN-2 (Compound 38) is a small-molecule research reagent that selectively inhibits fibroblast growth factor receptor 2 (FGFR2). It exhibits potent biochemical activity against FGFR2 with reduced activity versus FGFR1 and FGFR3, and is supplied as a powder for laboratory reconstitution and storage.
- Selective FGFR2 inhibition with IC50 of 29 nM.
- Differential activity for FGFR1 and FGFR3 (389 nM and 758 nM) supports isoform selectivity studies.
- Supplied as a powder for convenient reconstitution and long-term storage.
- Storage stability: powder stable at -20°C for 3 years and 4°C for 2 years.
- Molecular formula C23H22N4O and molecular weight 370.45 for dosing and calculations.
![Medchemexpress LLC N-[4-[(4R)-4-methyl-6-oxo-4,5-dihydro-1H-pyridazin-3-yl]phenyl]acetamide | 220246-81-1 | MFCD09952125 | 99.0% | C13H15N3O2 | 10MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000258422.png-250.jpg)
Medchemexpress LLC N-[4-[(4R)-4-methyl-6-oxo-4,5-dihydro-1H-pyridazin-3-yl]phenyl]acetamide | 220246-81-1 | MFCD09952125 | 99.0% | C13H15N3O2 | 10MG
OR-1896 is the active, long-lived metabolite of levosimendan with calcium-sensitizing and phosphodiesterase III (PDE III) inhibitory activity. It is used in pharmacological and in vivo research to study cardioprotective effects, myocardial contractility, and cardiac remodeling.
- Active metabolite with calcium-sensitizing and PDE III inhibitory properties.
- Demonstrated cardioprotective effects in preclinical studies.
- High solubility in DMSO for in vitro applications.
- Formulatable for in vivo dosing using several vehicle systems.
- High purity suitable for research use.
- Stable as a powder when stored at low temperatures.
MOLTOX Molecular Toxicology Inc 2X Yeast Extract Tryptone Broth, 1000 mL/bottle, Store in Refrigerator
This medium is a growth medium used for the cultivation of recombinant strains of E. coli. This nutritionally rich medium is also used in the propagation of M13 bacteriophage for phage display research. Each lot of media from MOLTOX is tested for sterility, where applicable, and its ability to support the growth of the appropriate microorganism. All media are accompanied by GLP-compliant formulation and Quality Control certificate.
Medchemexpress LLC Bis(2-ethylhexyl) phthalate | 117-81-7 | 99.56% | 100 MG
DEHP (Bis(2-ethylhexyl) phthalate) is a widely used plasticizer that is orally active. It can produce various toxic effects on organisms, including neurotoxicity, liver toxicity, immunotoxicity, and reproductive toxicity.
- Inhibits cell viability in mouse GC-1 spg cells
- Induces autophagy and apoptosis via oxidative stress
- Impairs fertility in female C3H/N mice
- Increases body weight and visceral fat tissue
- Increases expression of PPARα and PPARγ mRNA
Medchemexpress LLC Sirt7 inhibitor 97491 | 1807758-81-1 | 98.8% | C15H12ClN3O | 10MG
Sirt7 inhibitor 97491 is a small-molecule research reagent that selectively inhibits SIRT7 deacetylase activity, increases p53 acetylation at K373/382, and promotes apoptosis via caspase pathways. It is intended for biochemical and cell-based studies of SIRT7 function and related signaling pathways.
- Potent SIRT7 inhibition (IC50 325 nM).
- High purity (98.8%), suitable for research applications.
- Molecular formula C15H12ClN3O; molecular weight 285.73 g·mol⁻¹.
- Supplied as a solid, off-white to light yellow appearance.
- Storage: 4°C protected from light; in solution, -80°C (6 months) or -20°C (1 month).
- Available as mg-scale powders and DMSO solution for assays.
Medchemexpress LLC Lometrexol | 106400-81-1 | 99.0% | C21H25N5O6 | 1 MG
Lometrexol (DDATHF) is an antipurine antifolate that inhibits glycinamide ribonucleotide formyltransferase (GARFT) and de novo purine synthesis. It causes abnormal cell proliferation, apoptosis, and cell cycle arrest. Lometrexol exhibits anticancer activity and is a potent human Serine hydroxymethyltransferase1/2 (hSHMT1/2) inhibitor. It binds tightly to GART, depleting intracellular purine ribonucleotides.
- Antipurine antifolate
- Inhibits GARFT activity
- Inhibits de novo purine synthesis
- Induces abnormal cell proliferation and apoptosis
- Causes cell cycle arrest
- Exhibits anticancer activity
- Potent hSHMT1/2 inhibitor
- Depletes intracellular purine ribonucleotides
Medchemexpress LLC N-(pyridin-3-yl)thiophene-2-carboxamide | 62289-81-0 | MFCD00469725 | 99.7% | 204.25 g/mol | C10H8N2OS | 25MG
SW106065 (N-(pyridin-3-yl)thiophene-2-carboxamide; CAS 62289-81-0) is a small-molecule research compound that induces apoptosis and inhibits proliferation in malignant peripheral nerve sheath tumor (MPNST) cell lines in vitro and reduces tumor growth in mouse models. Supplied in high-purity solid and solution formats for laboratory research use only.
- High purity suitable for research applications.
- Available in multiple sizes and solution formats for experimental flexibility.
- Shown to induce apoptosis and inhibit MPNST cell proliferation in vitro.
- Demonstrated in vivo activity in mouse tumor models.
- Stable under recommended storage conditions for long-term use.
Biotium Progesterone(6-5E-3F), CF647 conjugate, 0.1mg/mL
This MAb is specific for progesterone. It exhibits minimal cross reactivity with related compounds in ELISA. It reacts with Progesterone-11a-HMS-BSA: 100%; 5-beta-Pregnane-3,20-dione: 48%; 5-alpha-Pregnane-3,20-dione: 26.4%; 17-alpha-Hydroxyprogesterone: 2.5%; 20-alpha-Hydroxyprogesterone: 0.04%. Progesterone is a steroid hormone synthesized from the cholesterol derivative, pregnenolone, in the cortex of the adrenal gland. Progesterone is secreted by the corpus luteum and acts to prepare the endometrium for the implantation of a fertilized egg. During pregnancy, it is secreted by the placenta to prevent spontaneous abortion and to stimulate the development of mammary tissue to produce milk. Thus, progesterone plays a central role in the reproductive events associated with the establishment and maintenance of pregnancy. Luteinized theca cells of normal ovary secrete progesterone. The determination of progesterone concentrations in the body fluids is of great value for endocrin
Alkali Scientific D Lactose Monohydrate, 500 G
D-Lactose Monohydrate is a versatile carbohydrate compound used in laboratory settings for microbiological applications and fermentation. This 500g bottle of lactose monohydrate provides a stable, solid source of lactose for fermentation experiments and microbiological growth media. It serves as a key ingredient in culturing organisms that metabolize lactose, enabling research on enzyme activity, carbohydrate metabolism, and fermentation processes. Lactose Monohydrate is commonly used in the dairy industry and research on lactose-fermenting bacteria or yeast in food science and biotechnology studies.
General Laboratory Products MICROBIO .1PEPTONE 10ML 100/CS
Microbiology supplies, Media for microbiology, Culture media for microbiology, General Laboratory Products, (0.1%) Peptone Water, 10 ML, 16 x 125 Glass Tube, 100/CS
Sigma Aldrich Fine Chemicals Biosciences alpha-Lactose monohydrate BioXtra, >=99% total lactose basis (GC) | 5989-81-1 | MFCD00150747 | 10MG
alpha-Lactose monohydrate BioXtra, >=99% total lactose basis (GC) | Purity: >=99% total lactose basis (GC) | Mol Wt: 360.31 | 5989-81-1 | MFCD00150747 | 10MG
General Laboratory Products MICROBIO FLUIDA 1000ML 6/CS
Microbiology supplies, Media for microbiology, Culture media for microbiology, General Laboratory Products, Fluid A, 1000 ML, W/M Jar, 6/CS
Biotium Progesterone(6-5E-3F), CF647 conjugate, 0.1mg/mL
This MAb is specific for progesterone. It exhibits minimal cross reactivity with related compounds in ELISA. It reacts with Progesterone-11a-HMS-BSA: 100%; 5-beta-Pregnane-3,20-dione: 48%; 5-alpha-Pregnane-3,20-dione: 26.4%; 17-alpha-Hydroxyprogesterone: 2.5%; 20-alpha-Hydroxyprogesterone: 0.04%. Progesterone is a steroid hormone synthesized from the cholesterol derivative, pregnenolone, in the cortex of the adrenal gland. Progesterone is secreted by the corpus luteum and acts to prepare the endometrium for the implantation of a fertilized egg. During pregnancy, it is secreted by the placenta to prevent spontaneous abortion and to stimulate the development of mammary tissue to produce milk. Thus, progesterone plays a central role in the reproductive events associated with the establishment and maintenance of pregnancy. Luteinized theca cells of normal ovary secrete progesterone. The determination of progesterone concentrations in the body fluids is of great value for endocrin
General Laboratory Products MICROBIO FLUIDD 500ML 12/CS
Microbiology supplies, Media for microbiology, Culture media for microbiology, General Laboratory Products, Fluid D, 500 ML, W/M Jar, 12/CS